α1-Syntrophin-deficient mice exhibit impaired muscle force recovery after osmotic shock.
Muscle Nerve
; 49(5): 728-35, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24037898
ABSTRACT
INTRODUCTION:
α1-syntrophin, a member of the dystrophin complex, recruits membrane molecules, including aquaporin-4, at the sarcolemma. The physiological functions of α1-syntrophin are poorly understood.METHODS:
We examined the physiological characteristics of α1-syntrophin-deficient muscles under osmotic stress conditions to test the possibility that mutant muscles are less tolerant of osmotic shock.RESULTS:
Isolated muscle bundles from mutant mice showed markedly reduced force production after hypo-osmotic shock. In addition, the mutant muscle bundles showed delayed recovery of specific gravity after being exposed to hypo-osmotic conditions. Two consecutive exercise tests on the treadmill revealed their performance in the second test was significantly lower than for wild-type mice. Furthermore, mutant mice had higher serum lactate concentrations after treadmill exercise.CONCLUSIONS:
Although the lack of α1-syntrophin from the sarcolemma does not lead to muscle degeneration, our results suggest that it may be partly involved in the pathophysiology of dystrophin-deficient Duchenne muscular dystrophy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pressão Osmótica
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Proteínas de Ligação ao Cálcio
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Músculo Esquelético
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Fibras Musculares Esqueléticas
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Fadiga Muscular
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Distrofia Muscular de Duchenne
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Força Muscular
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Proteínas de Membrana
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Proteínas Musculares
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article