The energetic state of mitochondria modulates complex III biogenesis through the ATP-dependent activity of Bcs1.
Cell Metab
; 18(4): 567-77, 2013 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-24055101
ABSTRACT
Our understanding of the mechanisms involved in mitochondrial biogenesis has continuously expanded during the last decades, yet little is known about how they are modulated to optimize the functioning of mitochondria. Here, we show that mutations in the ATP binding domain of Bcs1, a chaperone involved in the assembly of complex III, can be rescued by mutations that decrease the ATP hydrolytic activity of the ATP synthase. Our results reveal a Bcs1-mediated control loop in which the biogenesis of complex III is modulated by the energy-transducing activity of mitochondria. Although ATP is well known as a regulator of a number of cellular activities, we show here that ATP can be also used to modulate the biogenesis of an enzyme by controlling a specific chaperone involved in its assembly. Our study further highlights the intramitochondrial adenine nucleotide pool as a potential target for the treatment of Bcs1-based disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trifosfato de Adenosina
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Complexo III da Cadeia de Transporte de Elétrons
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Chaperonas Moleculares
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Proteínas de Saccharomyces cerevisiae
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Proteínas Mitocondriais
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Proteínas de Membrana
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Mitocôndrias
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article