Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.
EMBO Rep
; 14(11): 992-8, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24060902
ABSTRACT
The BH3-only protein Bim is a critical initiator of apoptosis in hematopoietic cells. Bim is upregulated in response to growth factor withdrawal and in vitro studies have implicated the transcription factor Foxo3a as a critical inducer. To test the importance of this regulation in vivo, we generated mice with mutated Foxo-binding sites within the Bim promoters (Bim(ΔFoxo/ΔFoxo)). Contrary to Bim-deficient mice, Bim(ΔFoxo/ΔFoxo) mice had a normal hematopoietic system. Moreover, cytokine-dependent haematopoietic cells from Bim(ΔFoxo/ΔFoxo) and wt mice died at similar rates. These results indicate that regulation of Bim by Foxo transcription factors is not critical for the killing of hematopoietic cells.
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Proteínas Proto-Oncogênicas
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Apoptose
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Proteínas Reguladoras de Apoptose
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Fatores de Transcrição Forkhead
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Sistema Hematopoético
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article