Comparison of Mycobacterium lentiflavum and Mycobacterium avium-intracellulare complex lymphadenitis.
Pediatr Infect Dis J
; 33(1): 28-34, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24064561
ABSTRACT
BACKGROUND:
Mycobacterium lentiflavum is considered a rare pathogen causing nontuberculous mycobacterial (NTM) lymphadenitis.METHODS:
A multicenter, retrospective study was performed in immunocompetent children <14 years of age with microbiologically confirmed NTM lymphadenitis treated at 6 hospitals in Madrid, Spain, during 2000-2010. We compared children with M. lentiflavum and Mycobacterium avium-intracellulare complex infection.RESULTS:
Forty-five microbiologically confirmed NTM lymphadenitis patients were identified 19 (45.2%) caused by M. avium-intracellulare complex, 17 (40.5%) by M. lentiflavum, 1 by both and 5 by other mycobacteria. Out of 17 M. lentiflavum cases, 14 were diagnosed in the past 5 years. Regarding M. lentiflavum cases, median age was 23 months. Submandibular nodes were the most frequently involved (76.5%), with multiple locations seen in 41% of the children and spontaneous drainage in 41% of them. Drug susceptibility tests were performed in 14 isolates and showed a complete susceptibility to clarithromycin and cycloserine, whereas 93% were resistant to rifampin, 33% to quinolones and full resistance to other tested antimycobacterial drugs was detected. All but 1 child required surgery and 11 were treated additionally with various drug combinations. Total resolution was achieved in 50% of children within 6 months.Compared with M. avium-intracellulare complex cases, children were younger and laterocervical nodes were significantly less frequently involved. No statistically significant differences were found related to clinical characteristics, treatment and outcome.CONCLUSIONS:
M. lentiflavum is an emerging pathogen producing NTM lymphadenitis in Madrid.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexo Mycobacterium avium
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Infecção por Mycobacterium avium-intracellulare
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Linfadenite
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Mycobacterium
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article