Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria.
Chem Commun (Camb)
; 49(98): 11476-8, 2013 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-24064984
ABSTRACT
We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Perileno
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Fotoquimioterapia
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Neoplasias Encefálicas
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Fármacos Fotossensibilizantes
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Mitocôndrias
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article