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Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.
Bhutta, Mahmood F; Cheeseman, Michael T; Herault, Yann; Yu, Yuejin E; Brown, Steve D M.
Afiliação
  • Bhutta MF; Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Room 6607 Level 6, Headley Way, Oxford, OX3 9DU, UK, m.bhutta@doctors.org.uk.
Mamm Genome ; 24(11-12): 439-45, 2013 Dec.
Article em En | MEDLINE | ID: mdl-24068166
ABSTRACT
Chronic otitis media (OM) is common in Down syndrome (DS), but underlying aetiology is unclear. We analysed the entire available mouse resource of partial trisomy models of DS looking for histological evidence of chronic middle-ear inflammation. We found a highly penetrant OM in the Dp(16)1Yey mouse, which carries a complete trisomy of MMU16. No OM was found in the Dp(17)1Yey mouse or the Dp(10)1Yey mouse, suggesting disease loci are located only on MMU16. The Ts1Cje, Ts1RhR, Ts2Yah, and Ts65Dn trisomies and the transchomosomic Tc1 mouse did not develop OM. On the basis of these findings, we propose a two-locus model for chronic middle-ear inflammation in DS, based upon epistasis of the regions of HSA21 not in trisomy in the Tc1 mouse. We also conclude that environmental factors likely play an important role in disease onset.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Otite Média / Síndrome de Down Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Otite Média / Síndrome de Down Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article