CAR regulates epithelial cell junction stability through control of E-cadherin trafficking.
Sci Rep
; 3: 2889, 2013 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-24096322
ABSTRACT
CAR (Coxsackie and Adenovirus Receptor) is the primary docking receptor for typeB coxsackie viruses and subgroup C adenoviruses. CAR is a member of the JAM family of adhesion receptors and is located to both tight and adherens junctions between epithelial cells where it can assemble adhesive contacts through homodimerisation in trans. However, the role of CAR in controlling epithelial junction dynamics remains poorly understood. Here we demonstrate that levels of CAR in human epithelial cells play a key role in determining epithelial cell adhesion through control of E-cadherin stability at cell-cell junctions. Mechanistically, we show that CAR is phosphorylated within the C-terminus by PKCδ and that this in turn controls Src-dependent endocytosis of E-cadherin at cell junctions. This data demonstrates a novel role for CAR in regulating epithelial homeostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Caderinas
/
Células Epiteliais
/
Junções Intercelulares
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article