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A meta-analysis of treating acute traumatic brain injury with calcium channel blockers.
Xu, Gang-Zhu; Wang, Mao-De; Liu, Kai-Ge; Bai, Yin-An; Wu, Wei; Li, Wen.
Afiliação
  • Xu GZ; Department of Neurosurgery, Affiliated Hospital of Xi'an Medical University, No. 48, Fenghao West Road, Xi'an 710077, Shaanxi, China. Electronic address: xgz917@126.com.
Brain Res Bull ; 99: 41-7, 2013 Oct.
Article em En | MEDLINE | ID: mdl-24099981
The purpose of this systematic review was to evaluate and meta-analyse the current evidence for the use of calcium channel blockers (CCBs) in the treatment of acute traumatic brain injury (TBI) and traumatic subarachnoid haemorrhage (tSAH). A systematic search of clinical trials.gov, Cochrane library databases, EMBASE, MEDLINE, Web of science search and WHO trial registry, plus hand-searching of grey literature, was undertaken in March 2013. Two reviewers independently extracted the data using a pre-defined data extraction form. RevMan 5 software was used to synthesise data and calculate the risk ratio (RR) based on event rates as well as the 95% confidence interval (CI). Finally, nine RCTs with a total of 2182 patients were included. Meta-analysis showed that there was no difference between CCBs and control groups for rates of mortality (n=1337, 5 RCTs, RR 0.93 CI 0.77-1.12). In a subgroup tSAH analysis, the difference was not significant (n=389, 2 RCTs, RR 0.73 CI 0.53-1.02). There were slightly fewer unfavourable outcomes in the treatment group, but the difference was not statistically significant (n=2101, 8 RCTs, RR 0.90 CI 0.76-1.08). In the subgroup tSAH analysis, again, the difference did not reach statistical significance (n=1074, 5 RCTs, RR 0.95 CI 0.73-1.24). It seems that larger, well-designed RCTs are necessary in order to ascertain any clinical benefit CCBs may or may not have for the treatment of acute TBI.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Bloqueadores dos Canais de Cálcio Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Bloqueadores dos Canais de Cálcio Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article