Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry.
Opt Lett
; 38(16): 3017-20, 2013 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-24104636
ABSTRACT
We achieved continuous, noncontact wide-field imaging and characterization of drug release from a polymeric device in vitro by uniquely using off-axis interferometric imaging. Unlike the current gold-standard methods in this field, which are usually based on chromatography and spectroscopy, our method requires no user intervention during the experiment and involves less lab consumable instruments. Using a simplified interferometric imaging system, we experimentally demonstrate the characterization of anesthetic drug release (Bupivacaine) from a soy-based protein matrix, which is used as a skin substitute for wound dressing. Our results demonstrate the potential of interferometric imaging as an inexpensive and easy-to-use alternative for characterization of drug release in vitro.
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Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
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Pele Artificial
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Luz
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article