RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
Nat Rev Mol Cell Biol
; 14(11): 699-712, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24105322
The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Longo não Codificante
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article