Your browser doesn't support javascript.
loading
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
Geisler, Sarah; Coller, Jeff.
Afiliação
  • Geisler S; 1] Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA. [2] Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, 4058 Basel, Switzerland.
Nat Rev Mol Cell Biol ; 14(11): 699-712, 2013 Nov.
Article em En | MEDLINE | ID: mdl-24105322
The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article