The levels of carbohydrate antigen 19-9 are associated with gender and age in Chinese population.
Clin Lab
; 59(7-8): 813-7, 2013.
Article
em En
| MEDLINE
| ID: mdl-24133910
ABSTRACT
BACKGROUND:
CA 19-9 is one of the most frequently used biomarkers for tumors.METHODS:
We analyzed the influential factors of the Carbohydrate Antigen 19-9 (CA 19-9) levels in Chinese general population to better interpret the results of the CA 19-9 screening tests. 36,924 apparently healthy individuals and 1,335 patients with gastrointestinal (GI) tumors were involved in this study. Serum CA 19-9 levels were measured using a Roche Cobas E601.RESULTS:
The serum CA 19-9 levels in apparently healthy individuals were correlated with age and gender. Its level was positively correlated with the age of males, while it showed a V-shape curve in female populations. This effect could be due to sex hormones, such as prolactin, which were found to have a negative effect on the level of CA 19-9 in the present study.CONCLUSIONS:
Our data indicates that gender and age could affect the CA19-9 serum level. We can set up different cut-off values according to the patient's gender and age, which can help us to get a more individualized representation in different populations.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Antígeno CA-19-9
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article