Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer.

Muñoz-Lopez, Martin; Medina, Pedro P; Garcia-Perez, Jose L

Muñoz-Lopez, Martin; Medina, Pedro P; Garcia-Perez, Jose L.

Afiliação

Muñoz-Lopez M; Department of Human DNA Variability, University of Granada, GENYO: Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avenue de la Ilustracion, 114, 18016 Granada, Spain.

Cancer Cell ; 24(4): 405-7, 2013 Oct 14.

Article em En | MEDLINE | ID: mdl-24135277

ABSTRACT

ABSTRACT

Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.

Assuntos

Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Proteína BRCA1/metabolismo; Metilação de DNA; Heterocromatina/metabolismo; Fosfoproteínas Fosfatases/metabolismo; Animais; Humanos; Masculino; Proteína Fosfatase 2C

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Heterocromatina / Fosfoproteínas Fosfatases / Proteína BRCA1 / Metilação de DNA / Proteínas Mutadas de Ataxia Telangiectasia Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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