Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.
Psychopharmacology (Berl)
; 231(4): 727-36, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24136220
ABSTRACT
RATIONALE Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:
The present experiments focused on the effects of the pro-inflammatory cytokine interleukin 1-beta (IL-1ß) on effort-related choice behavior.METHODS:
Rats were tested on a concurrent fixed ratio 5 lever pressing/chow feeding choice procedure, which assesses the tendency of rats to work for a preferred food (high carbohydrate pellets) in the presence of a concurrently available but less preferred substitute (laboratory chow).RESULTS:
IL-1ß (1.0-4.0 µg/kg IP) shifted choice behavior, significantly decreasing lever pressing and increasing intake of the freely available chow. The second experiment assessed the ability of the adenosine A2A antagonist (E)-phosphoric acid mono-[3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl] propyl] ester disodium salt (MSX-3) to reverse the behavioral effects of IL-1ß. MSX-3 attenuated the effort-related impairments produced by IL-1ß, increasing lever pressing and also decreasing chow intake. In the same dose range that shifted effort-related choice behavior, IL-1ß did not alter food intake or preference in parallel free-feeding choice studies, indicating that these low doses were not generally suppressing appetite or altering preference for the high carbohydrate pellets. In addition, IL-1ß did not affect core body temperature.CONCLUSIONS:
These results indicate that IL-1ß can reduce the tendency to work for food, even at low doses that do not produce a general sickness, malaise, or loss of appetite. This research has implications for the involvement of cytokines in motivational symptoms such as anergia and fatigue.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento de Escolha
/
Interleucina-1beta
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Comportamento Alimentar
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Motivação
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article