Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.

Sällström, Johan; Al-Saffar, Ahmad; Pehrson, Rikard

Sällström, Johan; Al-Saffar, Ahmad; Pehrson, Rikard.

Afiliação

Sällström J; Department of Safety Pharmacology, Safety Assessment Sweden, AstraZeneca R&D, Södertälje, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Al-Saffar A; Department of Safety Pharmacology, Safety Assessment Sweden, AstraZeneca R&D, Södertälje, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address: ahmad.al-saffar@medsci.uu.se.
Pehrson R; Department of Safety Pharmacology, Safety Assessment Sweden, AstraZeneca R&D, Södertälje, Sweden; AstraZeneca Research and Development, Respiratory and Inflammatory Innovative Medicines, Department of Drug Metabolism and Pharmacokinetics, Mölndal, Sweden.

J Pharmacol Toxicol Methods ; 69(1): 24-9, 2014.

Article em En | MEDLINE | ID: mdl-24140388

Assuntos

Antiarrítmicos/farmacologia; Antiarrítmicos/farmacocinética; Flecainida/farmacologia; Flecainida/farmacocinética; Frequência Cardíaca/efeitos dos fármacos; Síndrome do QT Longo/induzido quimicamente; Animais; Antiarrítmicos/sangue; Cães; Flecainida/sangue; Coração/efeitos dos fármacos; Masculino; Miocárdio/metabolismo; Canal de Sódio Disparado por Voltagem NAV1.5/metabolismo; Telemetria/métodos

Palavras-chave

Beagle dog; Electrocardiogram; Flecainide; Flecainide acetate (PubChem CID: 41022); Modeling; Nav1.5; Pharmacokinetics; QRS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do QT Longo / Flecainida / Frequência Cardíaca / Antiarrítmicos Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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