Dihaloiodoarenes: α,α-dihalogenation of phenylacetate derivatives.
J Am Chem Soc
; 135(44): 16312-5, 2013 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-24152071
ABSTRACT
A hypervalent iodine reagent-based α-carbonyl dihalogenation reaction is reported. Treating diazoacetate derivatives with either iodobenzene dichloride or iodotoluene difluoride results in gem-dichlorination or gem-difluorination products, respectively. The reaction is catalyzed by either Lewis acid or Lewis base activation of the aryl-λ(3)-iodane (ArIX2) species and proceeds rapidly and chemoselectively to the desired gem-difunctionalized products in good to excellent yield.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article