Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699.
Bioorg Med Chem Lett
; 23(23): 6243-7, 2013 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-24157369
ABSTRACT
Two new benzodioxane derivatives were synthesized as candidates to image the serotonin 4 receptors by positron emission tomography (PET) and radiolabeled with fluorine-18 via a two-step procedure. Competition binding assays demonstrated that MNI-698 and MNI-699 had sub-nanomolar binding affinities against rat striatal 5-HT4 receptors (Ki of 0.20 and 0.07 nM, respectively). PET imaging in rhesus monkey showed that the regional brain distribution of [(18)F]MNI-698 and [(18)F]MNI-699 were consistent with the known densities of 5-HT4 in brain. [(18)F]MNI-698 and [(18)F]MNI-699 are among the first fluorine-18 radiotracers developed for imaging the 5-HT4 receptors in vivo and are currently under preclinical investigation in primates for future human use.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
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Encéfalo
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Radioisótopos de Flúor
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Compostos Radiofarmacêuticos
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Receptores 5-HT4 de Serotonina
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Dioxanos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article