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Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.
Liu, Sheng-Hung; Lin, Chao-Hsiung; Liang, Fong-Ping; Chen, Pei-Fen; Kuo, Cheng-Deng; Alam, Mohd Mujahid; Maiti, Barnali; Hung, Shih-Kai; Chi, Chin-Wen; Sun, Chung-Ming; Fu, Shu-Ling.
Afiliação
  • Liu SH; Department and Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan; Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 11221, Taiwan.
  • Lin CH; Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 11221, Taiwan; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 11221, Taiwan.
  • Liang FP; Institute of Traditional Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
  • Chen PF; Institute of Traditional Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
  • Kuo CD; Department of Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
  • Alam MM; Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30013, Taiwan.
  • Maiti B; Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30013, Taiwan.
  • Hung SK; Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.
  • Chi CW; Department and Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan; Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 11221, Taiwan.
  • Sun CM; Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30013, Taiwan. Electronic address: cmsun@mail.nctu.edu.tw.
  • Fu SL; Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 11221, Taiwan; Institute of Traditional Medicine, National Yang-Ming University, Taipei 11221, Taiwan. Electronic address: slfu@ym.edu.tw.
Biochem Pharmacol ; 87(2): 229-42, 2014 Jan 15.
Article em En | MEDLINE | ID: mdl-24161787
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genes abl / Genes src / Espécies Reativas de Oxigênio / Proteínas de Choque Térmico HSP90 / Diterpenos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genes abl / Genes src / Espécies Reativas de Oxigênio / Proteínas de Choque Térmico HSP90 / Diterpenos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article