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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Hartwell, Kimberly A; Miller, Peter G; Mukherjee, Siddhartha; Kahn, Alissa R; Stewart, Alison L; Logan, David J; Negri, Joseph M; Duvet, Mildred; Järås, Marcus; Puram, Rishi; Dancik, Vlado; Al-Shahrour, Fatima; Kindler, Thomas; Tothova, Zuzana; Chattopadhyay, Shrikanta; Hasaka, Thomas; Narayan, Rajiv; Dai, Mingji; Huang, Christina; Shterental, Sebastian; Chu, Lisa P; Haydu, J Erika; Shieh, Jae Hung; Steensma, David P; Munoz, Benito; Bittker, Joshua A; Shamji, Alykhan F; Clemons, Paul A; Tolliday, Nicola J; Carpenter, Anne E; Gilliland, D Gary; Stern, Andrew M; Moore, Malcolm A S; Scadden, David T; Schreiber, Stuart L; Ebert, Benjamin L; Golub, Todd R.
Afiliação
  • Hartwell KA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Miller PG; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Mukherjee S; Harvard Medical School, Boston, MA 02115, USA.
  • Kahn AR; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Stewart AL; Harvard Medical School, Boston, MA 02115, USA.
  • Logan DJ; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Negri JM; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
  • Duvet M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Järås M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Puram R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Dancik V; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Al-Shahrour F; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Kindler T; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Tothova Z; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Chattopadhyay S; Harvard Medical School, Boston, MA 02115, USA.
  • Hasaka T; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Narayan R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Dai M; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Huang C; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Shterental S; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Chu LP; Harvard Medical School, Boston, MA 02115, USA.
  • Haydu JE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Shieh JH; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Steensma DP; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Munoz B; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Bittker JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Shamji AF; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Clemons PA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Tolliday NJ; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Carpenter AE; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Gilliland DG; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Stern AM; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
  • Moore MAS; Harvard Medical School, Boston, MA 02115, USA.
  • Scadden DT; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Schreiber SL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Ebert BL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Nat Chem Biol ; 9(12): 840-848, 2013 Dec.
Article em En | MEDLINE | ID: mdl-24161946
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Ensaios de Seleção de Medicamentos Antitumorais / Leucemia / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Ensaios de Seleção de Medicamentos Antitumorais / Leucemia / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article