Cells or signals: which moves to drive skin pattern formation?
Exp Dermatol
; 22(12): 795-6, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24164411
ABSTRACT
During its development, the skin produces an array of evenly spaced hair follicles. How the location of each follicle is determined to produce this pattern has been the subject of study and speculation for several decades. A central unresolved issue is the extent to which movement of scattered, precommitted follicle cells might play a role in this process. Xavier et al. now report the identification of subpopulations of dermal cells in developing sheep skin which are positive for Delta1 expression, suggesting that these cells may represent precommitted dermal papilla cells and that dermal Notch pathway signalling plays a role in hair follicle patterning.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Regulação da Expressão Gênica no Desenvolvimento
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Folículo Piloso
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Peptídeos e Proteínas de Sinalização Intracelular
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Receptores Notch
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article