Yeast PPR proteins, watchdogs of mitochondrial gene expression.
RNA Biol
; 10(9): 1477-94, 2013.
Article
em En
| MEDLINE
| ID: mdl-24184848
ABSTRACT
PPR proteins are a family of ubiquitous RNA-binding factors, found in all the Eukaryotic lineages, and are particularly numerous in higher plants. According to recent bioinformatic analyses, yeast genomes encode from 10 (in S. pombe) to 15 (in S. cerevisiae) PPR proteins. All of these proteins are mitochondrial and very often interact with the mitochondrial membrane. Apart from the general factors, RNA polymerase and RNase P, most yeast PPR proteins are involved in the stability and/or translation of mitochondrially encoded RNAs. At present, some information concerning the target RNA(s) of most of these proteins is available, the next challenge will be to refine our understanding of the function of the proteins and to resolve the yeast PPR-RNA-binding code, which might differ significantly from the plant PPR code.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Fúngicas
/
Regulação Fúngica da Expressão Gênica
/
Proteínas de Ligação a RNA
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Mitocôndrias
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article