2 L versus 4 L of PEG3350 + electrolytes for outpatient colonic preparation: a randomized, controlled trial.
Gastrointest Endosc
; 79(3): 408-416.e4, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24206747
ABSTRACT
BACKGROUND:
Low-volume bowel preparations are ideal to ensure patient compliance, thus enabling high-quality examinations to be achieved.OBJECTIVES:
To examine the bowel-cleansing efficacy and patient tolerability of split-dose 2 L PEG3350 + electrolytes (PEG3350e) with 15 mg bisacodyl versus split-dose 4 L PEG3350e.DESIGN:
Single-blinded, noninferiority, randomized, controlled trial.SETTING:
Single site, university-affiliated tertiary care center. PATIENTS A total of 325 consecutive patients undergoing elective outpatient colonoscopy. INTERVENTION 2 L of PEG3350e with 15 mg bisacodyl versus 4 L of PEG3350e, both given in a split-dose fashion. MAIN OUTCOME MEASUREMENTS Efficacy and tolerability of a split dose of 2 L of PEG3350e with 15 mg bisacodyl. Efficacy was assessed by using the Boston Bowel Preparation Scale and Ottawa Bowel Preparation Scale. Patient satisfaction and tolerability were assessed by using a short survey.RESULTS:
A total of 325 patients were included in the intention-to-treat analysis (51% male) with a mean ± standard deviation age of 56 ± 11.2 years. No statistically significant difference in cleanliness was found by using the Boston Bowel Preparation Scale (intention-to-treat, P = .381; per-protocol, P = .387) and the Ottawa Bowel Preparation Scale (intention-to-treat, P = .285; per-protocol, P = .334). Participants receiving 2 L of PEG3350e found the preparation easy to consume and were willing to repeat the procedure more often than the 4-L group (P < .001).LIMITATIONS:
Single-center study looking at outpatient colonoscopies; unable to comment on adenoma detection rate.CONCLUSIONS:
Bowel-cleansing efficacy was similar in both the 2-L and 4-L PEG3350e groups; however, patient tolerability and willingness to repeat preparation were statistically greater with the 2 L of PEG3350e with 15 mg bisacodyl regimen.
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Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Catárticos
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Colonoscopia
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article