Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice.

Huang, Zan; Ruan, Hai-Bin; Zhang, Zeng-Di; Chen, Weiqian; Lin, Zhaoyu; Zeng, Hu; Gao, Xiang

Huang, Zan; Ruan, Hai-Bin; Zhang, Zeng-Di; Chen, Weiqian; Lin, Zhaoyu; Zeng, Hu; Gao, Xiang.

Afiliação

Huang Z; MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Ruan HB; MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Zhang ZD; Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Chen W; MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China; Institute for Cardiovascular Science, Soochow University, Suzhou, China; Department of Cardiovascular Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.
Lin Z; MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Zeng H; MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Gao X; MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China. Electronic address: gaoxiang@nju.edu.cn.

Am J Pathol ; 184(1): 122-32, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24211109

Assuntos

Janus Quinase 2/metabolismo; Transtornos Mieloproliferativos/genética; Transtornos Mieloproliferativos/metabolismo; Mutação Puntual; Proteínas Proto-Oncogênicas c-kit/genética; Animais; Modelos Animais de Doenças; Ativação Enzimática/genética; Citometria de Fluxo; Células HEK293; Humanos; Immunoblotting; Imunoprecipitação; Camundongos; Camundongos Mutantes; Estrutura Terciária de Proteína; Transfecção

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mutação Puntual / Proteínas Proto-Oncogênicas c-kit / Janus Quinase 2 / Transtornos Mieloproliferativos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google