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Hepatitis B virus infection among HIV-infected pregnant women in Malawi and transmission to infants.
Chasela, Charles S; Kourtis, Athena P; Wall, Patrick; Drobeniuc, Jan; King, Caroline C; Thai, Hong; Teshale, Eyasu H; Hosseinipour, Mina; Ellington, Sascha; Codd, Mary B; Jamieson, Denise J; Knight, Rod; Fitzpatrick, Patricia; Kamili, Saleem; Hoffman, Irving; Kayira, Dumbani; Mumba, Noel; Kamwendo, Deborah D; Martinson, Francis; Powderly, William; Teo, Chong-Gee; van der Horst, Charles.
Afiliação
  • Chasela CS; UNC Project, P/Bag A-104, Lilongwe, Malawi; School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield Dublin 4, Ireland.
  • Kourtis AP; Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: apk3@cdc.gov.
  • Wall P; School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield Dublin 4, Ireland.
  • Drobeniuc J; Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • King CC; Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Thai H; Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Teshale EH; Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Hosseinipour M; UNC Project, P/Bag A-104, Lilongwe, Malawi; School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
  • Ellington S; Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Codd MB; School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield Dublin 4, Ireland.
  • Jamieson DJ; Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Knight R; Westat, Rockville, MD, USA.
  • Fitzpatrick P; School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield Dublin 4, Ireland.
  • Kamili S; Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Hoffman I; School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
  • Kayira D; UNC Project, P/Bag A-104, Lilongwe, Malawi.
  • Mumba N; UNC Project, P/Bag A-104, Lilongwe, Malawi.
  • Kamwendo DD; UNC Project, P/Bag A-104, Lilongwe, Malawi.
  • Martinson F; UNC Project, P/Bag A-104, Lilongwe, Malawi.
  • Powderly W; School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield Dublin 4, Ireland.
  • Teo CG; Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • van der Horst C; School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
J Hepatol ; 60(3): 508-14, 2014 Mar.
Article em En | MEDLINE | ID: mdl-24211737
BACKGROUND & AIMS: The extent of HBV infection to infants of HBV/HIV-coinfected pregnant women in sub-Saharan Africa is unknown. The aim of this study was to assess prevalence of HBV infection among antiretroviral-naïve, HIV-infected pregnant women in Malawi and examine HBV transmission to their infants. METHODS: Plasma from 2048 HIV-infected, Malawian women and their infants were tested for markers of HBV infection. Study participants were provided standard-of-care health services, which included administration of pentavalent vaccine to infants at 6, 10, and 14 weeks of age. RESULTS: One-hundred and three women (5%) were HBsAg-positive; 70 of these HBsAg-positive women were also HBV-DNA-positive. Sixteen women (0.8%) were HBV-DNA-positive but HBsAg-negative. Five of 51 infants (9.8%) born to HBsAg-positive and/or HBV-DNA-positive women were HBV-DNA-positive by 48 weeks of age.HBV DNA concentrations of two infants of mothers who received extended lamivudine-containing anti-HIV prophylaxis were <4 log10 IU/ml compared to ⩾ 8 log10 IU/ml in three infants of mothers who did not. CONCLUSIONS: HBV DNA was detected in nearly 10% of infants born to HBV/HIV-coinfected women. Antenatal testing for HIV and HBV, if instituted, can facilitate implementation of prophylactic measures against infant infection by both viruses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Transmissão Vertical de Doenças Infecciosas / Coinfecção / Hepatite B Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Infant / Newborn / Pregnancy País como assunto: Africa Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Transmissão Vertical de Doenças Infecciosas / Coinfecção / Hepatite B Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Infant / Newborn / Pregnancy País como assunto: Africa Idioma: En Ano de publicação: 2014 Tipo de documento: Article