Aß-induced microglial cell activation is inhibited by baicalin through the JAK2/STAT3 signaling pathway.
Int J Neurosci
; 124(8): 609-20, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24219385
ABSTRACT
Baicalin has shown multiple neuroprotective biological activities, including antiapoptotic and anti-inflammatory functions in neurodegeneration diseases. However, whether baicalin can regulate Aß-induced microglial activation or inhibit inflammatory cytokine secretion has not been confirmed. We demonstrated that baicalin can inhibit beta amyloid peptides (Aß42)-induced BV2 microglial cell proliferation, reduce the expression of CD11b, decrease chemotactic ability of BV2 cells and significantly inhibit the secretion of IL-6, TNF-α and NO. Moreover, baicalin pretreatment can effectively inhibit Aß-induced phosphorylation of JAK2 and STAT3. Baicalin can inhibit Aß-induced microglial cell activation by regulating the JAK2/STAT3 signaling pathway in AD transgenic mice. The modulation of microglial proliferation, activation and secretion by baicalin could be a promising therapeutic option for the treatment of Alzheimer's disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Flavonoides
/
Transdução de Sinais
/
Peptídeos beta-Amiloides
/
Microglia
/
Fator de Transcrição STAT3
/
Janus Quinase 2
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article