Bifidobacterium bifidum PRL2010 modulates the host innate immune response.
Appl Environ Microbiol
; 80(2): 730-40, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24242237
ABSTRACT
Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bifidobacterium
/
Probióticos
/
Imunidade Inata
/
Intestinos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article