Detection of gamma-irradiation effect on DNA and protein using magnetic sensor and cyclic voltammetry.
J Nanosci Nanotechnol
; 13(11): 7250-3, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24245238
ABSTRACT
In this study, a magnetic sensor utilizing Planar Hall Resistance (PHR) and cyclic Voltammetry (CV) for detecting the radiation effect was fabricated. Specifically, we applied in parallel a PHR sensor and CV device to monitor the irradiation effect on DNA and protein respectively. Through parallel measurements, we demonstrated that the PHR sensor and CV are sensitive enough to measure irradiation effect. The PHR voltage decreased by magnetic nanobead labeled DNA was slightly recovered after gamma ray irradiation. The behavior of cdk inhibitor protein p21 having a sandwich structure of Au/protein G/Ab/Ag/Ab was checked by monitoring the cyclic Voltammetry signal in analyzing the gamma ray irradiation effect.
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
DNA
/
Técnicas Biossensoriais
/
Separação Imunomagnética
/
Inibidor de Quinase Dependente de Ciclina p21
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article