Diterpenoid alkaloids and flavonoids from Delphinium trichophorum.
Phytochemistry
; 97: 88-95, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24256579
ABSTRACT
Five hetisane-type C20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-ß-D-glucopyranoside, and quercetin 3-O-ß-D-glucopyranoside-7-O-α-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.03 to 52.79 µM.
Palavras-chave
Delnudine-type diterpenoid alkaloid; Delphinium trichophorum Franch; Diterpenoid alkaloid; Hetisane-type diterpenoid alkaloid; KRXFYFOHIOSSNE-ZXMOXNTFSA-N; Ranunculaceae; ULBJMFAWRDNRAM-JCTIUFQSSA-N; VPGOXBOVBANQMB-OQWYUALGSA-N; WDOZPTBXHDZRAC-GJGFCZQESA-N; WNZAQACNVGQHRH-NRNHFJSPSA-N; YPJJUKPGIAXPIU-RAXXLDHPSA-N
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Delphinium
/
Diterpenos
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Alcaloides
/
Antineoplásicos
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article