Synthesis, cytostatic, and antitumor properties of new rh(i) thiazole complexes.
Biol Trace Elem Res
; 8(4): 251-61, 1985 Dec.
Article
em En
| MEDLINE
| ID: mdl-24258015
ABSTRACT
Six new organometallic derivatives of Rh(I), belonging to the general structure [Rh(CO)2(L)(Cl)], were synthesized and characterized by chemical analysis and IR determinations. The following ligands (L) were employed 2-aminothiazole, thiazole, 2-amino-6-bromobenzothiazole, 5-chloro-2-methylthiobenzothiazole, 2-bromo-thiazole, and 2-isopropylthiazole. These new complexes were assayed in vitro with KB cells and in vivo with mice bearing established P388 and L1210 leukemias. Assays against S180 and Ehrlich ascitic tumors were also performed. Two complexes displayed antitumor activity against ascitic tumors.
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MEDLINE
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En
Ano de publicação:
1985
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Article