How I treat leukemia during pregnancy.
Blood
; 123(7): 974-84, 2014 Feb 13.
Article
em En
| MEDLINE
| ID: mdl-24269956
ABSTRACT
Leukemia in pregnancy remains a challenging therapeutic prospect. The prevalence is low at â¼1 in 10 000 pregnancies, and as a result data are limited to small retrospective series and case reports, rendering evidence-based recommendations for management strategies difficult. The management of the leukemias in pregnancy requires close collaboration with obstetric and neonatology colleagues as both the maternal and fetal outcomes must be taken into consideration. The decision to introduce or delay chemotherapy must be balanced against the impact on maternal and fetal survival and morbidity. Invariably, acute leukemia diagnosed in the first trimester necessitates intensive chemotherapy that is likely to induce fetal malformations. As delaying treatment in this situation is usually inappropriate, counseling with regard to termination of pregnancy is often essential. For chronic disease and acute leukemia diagnosed after the second trimester, therapeutic termination of the pregnancy is not inevitable and often, standard management approaches similar to those in nongravid patients can be used. Here, the management of the acute and chronic leukemias will be addressed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Neoplásicas na Gravidez
/
Leucemia
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article