[Diagnostic value of ultrasonography in combination with mammography for breast cancer within 2 cm: a meta-analysis].

ABSTRACT

OBJECTIVE: To evaluate the diagnostic value of ultrasonography in combination with mammography for breast cancer within 2 cm. METHODS: The PubMed, the Cochrane Library, CNKI, CBM and Wanfang databases (2003/01/01-2013/04/30) were searched for studies of the diagnostic value of ultrasonography in combination with mammography for breast cancer within 2 cm. The quality of the included studies was evaluated according to QUADAS items. The pooled sensitivity (SEN), pooled specificity (SPE), pooled diagnostic odds ratio (DOR), and area under summary receiver operating characteristic curve (AUC) were calculated using Review Manager 5.2 and Meta-DiSc 1.4 software. RESULTS: Nine articles were included in the final analysis. The pooled SEN of ultrasonography, mammography and their combination were 0.75, 0.66, and 0.92, the pooled SPE 0.75, 0.83, and 0.82, the pooled DOR 7.11, 8.67, and 60.82, and the AUC 0.7902, 0.8120, and 0.9469, respectively. CONCLUSION: The combination of ultrasonography and mammography can increase the diagnostic accuracy for breast cancer within 2 cm.