Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS).
Crit Rev Toxicol
; 43(10): 850-91, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24274377
ABSTRACT
The Globally Harmonised System of Classification (GHS) is a framework within which the intrinsic hazards of substances may be determined and communicated. It is not a legislative instrument per se, but is enacted into national legislation with the appropriate legislative instruments. GHS covers many aspects of effects upon health and the environment, including adverse effects upon sexual function and fertility or on development. Classification for these effects is based upon observations in humans or from properly designed experiments in animals, although only the latter is covered herein. The decision to classify a substance based upon experimental data, and the category of classification ascribed, is determined by the level of evidence that is available for an adverse effect on sexual function and fertility or on development that does not arise as a secondary non-specific consequence of other toxic effect. This document offers guidance on the determination of level of concern as a measure of adversity, and the level of evidence to ascribe classification based on data from tests in laboratory animals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reprodução
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Substâncias Perigosas
Tipo de estudo:
Guideline
/
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article