The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.
FEBS Lett
; 208(1): 63-6, 1986 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-2429869
ABSTRACT
ATP-sensitive K+ channels in inside-out membrane patches from dispersed rat pancreatic B-cells were studied using patch-clamp methods. The dose-response curve for ATP-induced channel inhibition was shifted to higher concentrations in the presence of ADP (2 mM). In glucose-free solution, the total intracellular concentration of ATP was 3.8 mM and of ADP 1.5 mM; glucose (20 mM) increased ATP and decreased ADP by approx. 40%. These results suggest that both ADP and ATP may be involved in regulating the activity of the glucose-sensitive K+ channel in intact B-cells.
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Base de dados:
MEDLINE
Assunto principal:
Difosfato de Adenosina
/
Trifosfato de Adenosina
/
Ilhotas Pancreáticas
/
Canais Iônicos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article