Silylation-based kinetic resolution of α-hydroxy lactones and lactams.
Org Lett
; 15(24): 6132-5, 2013 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-24299179
ABSTRACT
A silylation-based kinetic resolution has been developed for α-hydroxy lactones and lactams employing the chiral isothiourea catalyst (-)-benzotetramisole and triphenylsilyl chloride as the silyl source. The system is more selective for lactones than lactams, and selectivity factors up to 100 can be achieved utilizing commercially available reagents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Silanos
/
Lactamas
/
Lactonas
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article