Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis.
Science
; 342(6163): 1243-6, 2013 Dec 06.
Article
em En
| MEDLINE
| ID: mdl-24311691
ABSTRACT
Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin α (sLTα3) produced by RORγt(+) innate lymphoid cells (ILCs) controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin ß (LTα1ß2) produced by RORγt(+) ILCs is critical for T cell-independent IgA induction in the lamina propria via control of dendritic cell functions. Ablation of LTα in RORγt(+) cells abrogated IgA production in the gut and altered microbiota composition. Thus, soluble and membrane-bound lymphotoxins produced by ILCs distinctly organize adaptive immune responses in the gut and control commensal microbiota composition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos
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Linfotoxina-alfa
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Microbiota
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Mucosa Intestinal
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Intestino Delgado
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article