GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation.

Chen, Dan; Liu, Jinjiao; Rui, Bing; Gao, Min; Zhao, Ningwei; Sun, Shuai; Bi, Aijing; Yang, Tingting; Guo, Yingtao; Yin, Zhimin; Luo, Lan

Chen, Dan; Liu, Jinjiao; Rui, Bing; Gao, Min; Zhao, Ningwei; Sun, Shuai; Bi, Aijing; Yang, Tingting; Guo, Yingtao; Yin, Zhimin; Luo, Lan.

Afiliação

Chen D; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Liu J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Rui B; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Gao M; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Zhao N; School of Biotechnology, Royal Institute of Technology, No. 21, Roslagstullsbacken, Stockholm SE-10691, Sweden.
Sun S; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Bi A; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Yang T; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China.
Guo Y; Jiangsu Province Key Laboratory for Molecular and Medicine Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, People's Republic of China.
Yin Z; Jiangsu Province Key Laboratory for Molecular and Medicine Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, People's Republic of China. Electronic address: yinzhimin@njnu.edu.cn.
Luo L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, People's Republic of China. Electronic address: lanluo@nju.edu.cn.

Biochim Biophys Acta ; 1843(2): 454-63, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24321768

Assuntos

Angiotensina II/farmacologia; Movimento Celular/efeitos dos fármacos; Citoproteção/efeitos dos fármacos; Glutationa S-Transferase pi/metabolismo; Músculo Liso Vascular/citologia; Miócitos de Músculo Liso/citologia; Fator de Transcrição STAT3/metabolismo; Animais; Núcleo Celular/efeitos dos fármacos; Núcleo Celular/metabolismo; Proliferação de Células/efeitos dos fármacos; Técnicas de Silenciamento de Genes; Hipertrofia; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/enzimologia; Fator de Crescimento Derivado de Plaquetas/farmacologia; Ligação Proteica/efeitos dos fármacos; Transporte Proteico/efeitos dos fármacos; Ratos; Transdução de Sinais/efeitos dos fármacos; Quinases da Família src/metabolismo

Palavras-chave

3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-tetrazolium bromide; Ang II; Angiotensin II; DMSO; GSH; GSTpi; Glutathione S-transferase pi; JAK2; JNK; Janus-activated kinase 2; MTT; PBS; STAT3; Signal transducer and activator of transcription 3; TLK199; TNF-α; TRAF2; VSMCs; Vascular smooth muscle cells; angiotensin II; c-Jun NH2-terminal kinases; dimethylsulfoxide; g-glutamyl-S-(benzyl) cysteinyl-R-phenyl glycine diethyl ester; glutathione; glutathione S-transferase pi; phosphate buffered solution; signal transducer and activator of transcription 3; tumor necrosis factor alpha; tumor necrosis factor receptor-associated factor 2; vascular smooth muscle cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiotensina II / Movimento Celular / Citoproteção / Miócitos de Músculo Liso / Glutationa S-Transferase pi / Fator de Transcrição STAT3 / Músculo Liso Vascular Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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