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A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.
Cheng, Hailing; Liu, Pixu; Zhang, Fan; Xu, Erbo; Symonds, Lynn; Ohlson, Carolynn E; Bronson, Roderick T; Maira, Sauveur-Michel; Di Tomaso, Emmanuelle; Li, Jane; Myers, Andrea P; Cantley, Lewis C; Mills, Gordon B; Zhao, Jean J.
Afiliação
  • Cheng H; Authors' Affiliations: Department of Cancer Biology; Division of Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of Biological Chemistry and Molecular Pharmacology and Systems Biology; Rodent Histopathology Core, DF/HCC, Harvard Medical School; Department of Surgery, Brigham and Women's Hospital; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston; Novartis Institutes for Biomedical Research, Cambridge, Massacheusetts; Departme
Cancer Res ; 74(1): 15-23, 2014 Jan 01.
Article em En | MEDLINE | ID: mdl-24322983
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / PTEN Fosfo-Hidrolase / Serina-Treonina Quinases TOR Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / PTEN Fosfo-Hidrolase / Serina-Treonina Quinases TOR Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article