Characterization of galectin-1-positive cells in the mouse hippocampus.
Neuroreport
; 25(3): 171-6, 2014 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-24323124
ABSTRACT
Galectin-1 (gal-1) is one of several well-studied proteins from the galectin families. It is a 14.5 kDa glycoprotein with a single carbohydrate-binding domain. To examine the distribution and properties of gal-1 in the mouse hippocampus, we performed immunohistochemistry using an anti-gal-1 antibody. We found that most gal-1-positive cells showed both NeuN and ß-tubulin III (Tuj-1) immunoreactivity (NeuN 93%, ß-tubulin III 88%). Furthermore, we clarified that 77% of gal-1-positive cells expressed somatostatin, 79% of gal-1-positive cells expressed GAD67, 34% of gal-1-positive cells expressed parvalbumin, 5% of gal-1-positive cells expressed calretinin, 2% of gal-1-positive cells expressed calbindin, and 31% of gal-1-positive cells expressed neuropeptide Y in the mouse hippocampus. These results indicate that gal-1 is expressed in interneurons that also express ß-tubulin III and gal-1 may be a novel marker for interneuron subpopulations in the hippocampus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Galectina 1
/
Hipocampo
/
Interneurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article