Making sense of HIV innate sensing.

Cox, Andrea L; Siliciano, Robert F

Cox, Andrea L; Siliciano, Robert F.

Afiliação

Cox AL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: acox@jhmi.edu.
Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21201, USA.

Immunity ; 39(6): 998-1000, 2013 Dec 12.

Article em En | MEDLINE | ID: mdl-24332027

ABSTRACT

ABSTRACT

Innate sensing of HIV is important in host control and pathogenesis. In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by the DNA sensor cCAS and contribute to differential pathogenesis of HIV-1 and HIV-2.

Assuntos

Capsídeo/imunologia; DNA Complementar/metabolismo; Células Dendríticas; Infecções por HIV/imunologia; HIV-1/imunologia; HIV-2/imunologia; Nucleotidiltransferases/metabolismo; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Infecções por HIV / Capsídeo / HIV-1 / HIV-2 / DNA Complementar / Nucleotidiltransferases Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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