Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection.
J Infect Dis
; 209(11): 1726-30, 2014 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-24338351
ABSTRACT
To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
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Vírus Chikungunya
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Infecções por Alphavirus
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Transmissão Vertical de Doenças Infecciosas
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Anticorpos Antivirais
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article