Intermittent versus every-day mesalazine therapy in preventing complications of diverticular disease: a long-term follow-up study.
Eur Rev Med Pharmacol Sci
; 17(23): 3244-8, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24338468
ABSTRACT
BACKGROUND:
Mesalazine seems to be effective in preventing recurrence of acute uncomplicated diverticulitis (AUD), but the optimal mesalazine scheme to achieve these results is still debated.AIM:
To assess the effectiveness of two different mesalazine-based treatments in preventing recurrence of AUD and the occurrence of other complications of diverticular disease (DD) during a long-term follow-up. PATIENTS ANDMETHODS:
We reviewed 311 patients suffer from recent episode of AUD and undergoing to mesalazine treatment 207 (group A, 105 males, median age 63 years, range 47-74 years) were treated with mesalazine 1.6 g for 10 days each month, whilst 104 (group B, 55 males, median age 65 years, range 50-72 years) were treated with mesalazine 1.6 g every day. Patients were followed-up every 6 months (median 7.5 months, range 5-13 months).RESULTS:
Patients were followed-up for a mean time of 3 years (range 12-72 months). Overall, occurrence of complication recurred more frequently in group A than in group B (p = 0.030, log-rank test). Acute diverticulitis recurred in 17 (8.2%) patients in group A and in 3 (2.9%) in group B; diverticular bleeding occurred in 4 (1.9%) patients in group A and in 1 (0.96%) patient in group B; surgery was required in 3 (1.4%) patients in group A and in no (0%) patient in group B.CONCLUSIONS:
This is the first study showing that long-term mesalazine treatment is significantly better that intermittent mesalazine treatment in preventing occurrence of DD complications after an attack of acute diverticulitis.
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Base de dados:
MEDLINE
Assunto principal:
Fármacos Gastrointestinais
/
Anti-Inflamatórios não Esteroides
/
Mesalamina
/
Diverticulose Cólica
/
Doença Diverticular do Colo
/
Divertículo do Colo
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article