Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes.
Diabet Med
; 31(6): 691-8, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24344757
ABSTRACT
AIMS:
To examine how fasting glucose and glucose tolerance are related to magnetic resonance imaging-assessed indicators of subclinical cerebrovascular disease and brain atrophy and their variation according to age, sex and education.METHODS:
Participants in the present study were 172 healthy, community-dwelling older adults. An oral glucose tolerance test was administered and magnetic resonance imaging performed. Fasting, 2-h, and 2-h area-under-the-curve glucose levels, their associations with subclinical cerebrovascular disease and brain atrophy, and their respective interactions with age, sex and education were examined.RESULTS:
A positive association between fasting glucose and subclinical cerebrovascular disease (but not brain atrophy) emerged; this association was more pronounced for participants with < 12 years of education; however, glucose tolerance was not related to subclinical cerebrovascular disease or brain atrophy.CONCLUSIONS:
Findings revealed a potential link between fasting glucose levels and the presence of subclinical cerebrovascular disease indicators - white matter hyperintensities and silent brain infarction - in older adults without diabetes and with an education level below high school. Additional research is needed to confirm these associations and to determine the need for interventions aimed at closely monitoring and preventing elevated glucose levels in this population to reduce the prevalence of subclinical cerebrovascular disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Encéfalo
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Transtornos Cerebrovasculares
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Diabetes Mellitus Tipo 2
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Angiopatias Diabéticas
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Nefropatias Diabéticas
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article