TSLP: A Key Regulator of Asthma Pathogenesis.
Drug Discov Today Dis Mech
; 9(3-4)2012 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-24348685
ABSTRACT
Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2) inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved in orchestrating the inflammation seen in asthma and other atopic diseases. Early research elucidated the role of TSLP on CD4+ T cells, and recent work has revealed the impact of TSLP on multiple cell types. Furthermore, TSLP plays an important role in the sequential progression of atopic dermatitis to asthma, clarifying the key role of TSLP in the pathogenesis of asthma, a finding with therapeutic implications.
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article