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Polyhedral oligomeric silsesquioxane-F68 hybrid vesicles for folate receptor targeted anti-cancer drug delivery.
Nair, Bindu P; Vaikkath, Dhanesh; Nair, Prabha D.
Afiliação
  • Nair BP; Division of Tissue Engineering and Regeneration Technologies, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram 695012, Kerala, India.
Langmuir ; 30(1): 340-7, 2014 Jan 14.
Article em En | MEDLINE | ID: mdl-24354352
Polyhedral Oligomeric Silsesquioxane (POSS)-F68 hybrid vesicles with an average diameter of 700 nm are produced using a stable solution of heterofunctional POSS having 3-aminopropyl and vinyl groups and pluronic F68 in ethanol-water mixture. Thermogram and zeta potential values evidence the spontaneous self-assembly of POSS into bilayers through H-bonding interaction between the aminopropyl groups, and the effective stabilization of the POSS-bilayers by amphiphilic F68 during solvent-evaporation to form the vesicles. The vesicles are noncytotoxic and dispersible in aqueous solvents through steric stabilization provided by the hydrophilic F68. A highly facile coinclusion method has been used for making doxorubicin and folic acid loaded vesicles. Doxorubicin loaded in the vesicles exhibits a controlled release profile in phosphate buffered saline. Confocal microscopic and flow cytometric studies on the endocytosis of the vesicles by HeLa and HOS cells prove that a noncovalent entrapment of excess folic acid in the vesicles through H-bonding is sufficient to enhance the uptake significantly. POSS-F68 vesicles in combination with folic acid and a chemotherapeutic can have potential for targeted intracellular anti-cancer drug delivery.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Sistemas de Liberação de Medicamentos / Compostos de Organossilício / Poloxâmero / Transportadores de Ácido Fólico / Ácido Fólico / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Sistemas de Liberação de Medicamentos / Compostos de Organossilício / Poloxâmero / Transportadores de Ácido Fólico / Ácido Fólico / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article