Autoimmune disease--pathogenesis through molecular mimicry at the tripeptide level.
Ann Acad Med Singap
; 15(4): 546-54, 1986 Oct.
Article
em En
| MEDLINE
| ID: mdl-2436563
ABSTRACT
Increasingly it is being discovered that short segments of proteins can provoke an immune response. Sequential determinants are as important as conformational determinants. It is the thesis of this paper that a string of three amino acid residues (a tripeptide) is antigenic when it is located on a large carrier, that is, when it is part of a protein. Conceptually this has great explanatory power in understanding (a) autoimmune phenomena (b) the intriguing finding that monoclonal antibodies which are supposed to be exquisitely specific cross-react with disparate, non-homologous proteins. Clinical syndromes such as the neuropathies of myeloma, hepatitis and multiple sclerosis are discussed in the light of this concept by computer analysis of the putative antigenic sites of myelin basic protein, hepatitis B and A proteins and measles peptides.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Doenças Autoimunes
/
Epitopos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article