Localization and treatment of familial malignant nonfunctional paraganglioma with iodine-131 MIBG: report of two cases.
J Nucl Med
; 28(4): 528-31, 1987 Apr.
Article
em En
| MEDLINE
| ID: mdl-2437268
ABSTRACT
Two cases of familial, malignant, nonfunctional paraganglioma are reported. Uptake of iodine-131 metaiodobenzylguanidine ([131I]MIBG) by the tumors and metastases was demonstrated. In the first case, with multicentric and locally invasive disease, [131I]MIBG correctly localized a right carotid body paraganglioma which had been missed arteriographically. In the second case, with widespread, symptomatic metastatic disease, a therapeutic dose of [131I]MIBG produced palliation of bone pain after the failure of radio- and chemotherapy. Uptake of [131I]MIBG by paragangliomas does not correlate with catecholamine secretory activity. Iodine-131 MIBG should be considered as a therapeutic option in unresectable, malignant paragangliomas which take up this radiopharmaceutical.
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Base de dados:
MEDLINE
Assunto principal:
Paraganglioma
/
Neoplasias Encefálicas
/
Corpo Carotídeo
/
Radioisótopos do Iodo
/
Iodobenzenos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article