Endothelial nitric oxide synthase polymorphism influences renal allograft outcome.
Clin Transplant
; 28(2): 223-8, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24372826
ABSTRACT
BACKGROUND:
Atherosclerotic lesions within the graft are considered to be a major cause of interstitial fibrosis/tubular atrophy (IF/TA). We evaluated the factors that influence the development of IF/TA and three- and five-yr graft survival including nitric oxide synthase (eNOS) and angiotensin II type 1 and type 2 receptor gene polymorphism.METHODS:
Seventy-one male and 35 female patients (age 34.9 ± 11.2 yr) who underwent living-related renal transplantation were included. Angiotensin type 1 and type 2 receptor gene polymorphisms and eNOS intron 4 gene polymorphism were analyzed. The pre- and post-transplant laboratory data, patient characteristics, acute rejection episodes, and presence of IF/TA were evaluated.RESULTS:
Patients with the bb allele of eNOS gene had a lower prevalence of post-transplant third year (12.6% and 38.5%, p = 0.005) and fifth year IF/TA (46.6% and 82.3%, p = 0.02) and a lower incidence of five-yr graft failure (35.4% and 55.6%, p < 0.005). The eNOS gene polymorphism was independent and was the most prominent factor associated with third and fifth year IF/TA (p = 0.01, RR 29.72, and p = 0.03, RR 4.1, respectively). No significant relationship existed when angiotensin II gene polymorphisms were considered.CONCLUSIONS:
We concluded that recipient eNOS gene polymorphism can predict IF/TA, and the presence of the bb allele is associated with better graft outcome.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Complicações Pós-Operatórias
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Transplante de Rim
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Óxido Nítrico Sintase Tipo III
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Sobrevivência de Enxerto
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Falência Renal Crônica
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article