Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles.
Appl Radiat Isot
; 85: 45-53, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24374072
ABSTRACT
Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac.
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Base de dados:
MEDLINE
Assunto principal:
Actínio
Tipo de estudo:
Health_economic_evaluation
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article