Luteolin, a bioflavonoid, attenuates azoxymethane-induced effects on mitochondrial enzymes in BALB/c mice.
Asian Pac J Cancer Prev
; 14(11): 6669-72, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24377586
ABSTRACT
Colon cancer (CRC) is a serious health problem throughout the world. Development of novel drugs without side effects for this cancer is crucial. Luteolin (LUT), a bioflavonoid, has many beneficial effects such as antioxidant, anti-inflammatory and anti-proliferative potential. was a potent chemical carcinogen used for the induction of colon cancer. Colon carcinogenesis was initiated by intraperitoneal injection of azoxymethane (AOM) to mice at the dose of 15 mg/body kg weight in Balb/C mice for 3 weeks. Mice were treated with LUT at the dose of 1.2 mg /body kg weight orally. Mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), α-keto dehydrogenase (α-KDH), succinate dehydrogenase (SDH) and the activities of respiratory chain enzymes NADH dehydrogenase and cytochrome c oxidase were found to be elevated in AOM-treated animals. Treatment with LUT decreased the activities of all the parameters significantly. Hence, LUT might be a potent anticancer agent against colorectal cancer.
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Base de dados:
MEDLINE
Assunto principal:
Azoximetano
/
Carcinógenos
/
Colo
/
Neoplasias do Colo
/
Luteolina
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article