[Expression of growth-associated protein 43 in the hippocampus of mesial temporal lobe epilepsy mouse model].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 35(6): 589-94, 2013 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-24382233
ABSTRACT
OBJECTIVE:
To explore the temporal and spatial distribution of growth-associated protein 43(GAP-43)and phosphorylated growth-associated protein 43(p-GAP-43)in the dentate gyrus of mesial temporal lobe epilepsy(MTLE)mouse model.METHODS:
MTLE mouse model was established by using the kainic acid(KA)induction. Immunohistochemistry and Western blotting were applied to detect the expressions of GAP-43 and p-GAP-43 in different stages of epileptogenesis.RESULTS:
Both in the epileptic and control mice, high GAP-43 expression level was detected in the dentate gyrus, hilus, and inner molecular layer of hippocampus. Decreased p-GAP-43 expression was detected 5 days, 2 weeks, and 5 weeks after KA-induced seizures.CONCLUSION:
The decreased p-GAP-43 expression in the duration of seizure may play an important role in the synaptic reorganization of the sclerotic hippocampus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína GAP-43
/
Epilepsia do Lobo Temporal
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Hipocampo
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article