Efficacy and mechanism of action of yin lai tang (lung-stomach treatment) in dyspepsia mouse infected by FM1 virus.
Acta Pol Pharm
; 70(6): 1107-15, 2013.
Article
em En
| MEDLINE
| ID: mdl-24383334
ABSTRACT
The aim of this study was to assess the efficacy and elaborate the mechanism of action of Yin Lai Tang (Lung-Stomach Treatment) on dyspepsia mouse infected by FM1 virus. Ninety male, 4 week old Kunming mouse with 12-14 g weight, were randomly divided into 9 groups, i.e., normal, infected, dyspepsia, ribavirin, Shuanghuanglian, Children's indigestion tablet, YinLaiTang high dose, YinLaiTang middle dose and YinLaiTang low dose, and these groups had been treated by according drugs to get objectives. Compared with normal group, lung index significantly (p < 0.01) increased in all groups except ribavirin group where lung index obviously (p < 0.05) increased. There was non-significant (p > 0.05) difference in the values of lung homogenate virus titer between dyspepsia group and other groups. Compared to normal group, there was variable degree of inflammatory cell infiltrations in respiratory tract structures in the animals of other groups, and there was a significant (p < 0.01) increase in the level of serum IL-6, IL-10, and TNF-alpha in infected and dyspepsia group and significant (p < 0.01) decrease in the level of serum IFN-gamma was observed. Compared with single clearing stomach method and single clearing lung approach, lung-stomach treatment reduced the level of IL-6 with non-significant difference (p > 0.05) and increased the level of IL-10 obviously, and compared with the single clearing lung method, there was a significant difference (p < 0.05). Compared with the single clearing stomach method and the single clearing lung method, the lung-stomach treatment method had a better efficacy and showed effects on the expression of pro-inflammatory factor and anti-inflammatory factor.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Vírus da Influenza A
/
Estômago
/
Medicamentos de Ervas Chinesas
/
Infecções por Orthomyxoviridae
/
Dispepsia
/
Pulmão
/
Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article